Grapheme-color synesthetes experience color, not physically present, when viewing symbols. Synesthetes cannot remember learning these associations. Must synesthetic percepts be formed during a sensitive period? Can they form later and be consistent? What determines their nature? We tested grapheme-color synesthete, MC2, before, during and after she studied Hindi abroad. We investigated whether novel graphemes elicited synesthetic percepts, changed with familiarity, and/or benefited from phonemic information. MC2 reported color percepts to novel Devanagari and Hebrew graphemes. MC2 monitored these percepts over 6 (...) months in a Hindi-speaking environment. MC2 and synesthete DN, reported synesthetic percepts for Armenian graphemes, or Cyrillic graphemes + phonemes over time. Synesthetes, not controls, reported color percepts for novel graphemes that gained consistency over time. Phonemic information did not enhance consistency. Thus, synesthetes can form and consolidate percepts to novel graphemes as adults. These percepts may depend on pre-existing grapheme-color relationships but they can flexibly shift with familiarity. (shrink)

On Exceeding Determination and the Ideal of Reason: Immanuel Kant, William Desmond, and the Noumenological Principle examines the critical philosophy of Immanuel Kant, as it bears on theological principles. Focusing on the foundational ideas (of self, world, and God) that constitute Kant's metaphysical system, Shaw argues that these ideal projections of the rational structures of the thinking subject only conceal and obfuscate the more robust sense of the real that exists behind all phenomenal appearances. This book aims to critically assess (...) the theological content presented in the philosophy of Kant whilst reconstructing and developing some of Kant's more obscure points on the epistemological limitations of pure reason and the borders of knowledge itself. Shaw draws into dialogue with the writings of the contemporary philosopher William Desmond to demonstrate some of the problems of Kantian thought when it comes to the deeper mysteries of being. Desmondian philosophy proves to be a powerful influence over much of this work, as Shaw advances upon the delicate nexus where philosophy and theology convene. As a bold addition to this work, Shaw lays the groundwork for a new discourse in theology and the philosophy of religion: "Noumenology". Noumenology, which is Shaw's response to the deficiencies in methods concerning many of the modern approaches to phenomenology, is a call for the recalibration of the starting point for eidetic inquiry through the proposal of a non-discursive approach to the sensible, emotional, and intellectual - or perhaps, the all together spiritual. To accomplish this, Shaw reaches back to Kant for a heterodox approach to the language and content surrounding the noumenonal to set forth his theological interpretation of the "Noumenological Principle". (shrink)

I demonstrate that locking on, a key notion in Jerry Fodor's most recent theory of content, supplemented informational atomism (SIA), is cashed out in terms of asymmetric dependence, the central notion in his earlier theory of content. I use this result to argue that SIA is incompatible with the language of thought hypothesis because the constraints on the causal relations into which symbols can enter imposed by the theory of content preclude the causal relations needed between symbols for them to (...) serve as the elements of the medium of thought. (shrink)

Niniejszy artykuł jest jedną z kilku prac składających się na serię szczegółowych biografii biskupów Pafos w okresie pontyfikatu awiniońskiego. Na pierwszy rzut oka życie Héliego de Chambarlhac wydaje się być zwykłym odzwierciedleniem nepotyzmu, pluralizmu i absencji Kościoła zachodniego w ogóle, a zwłaszcza duchowieństwa łacińskiego na frankijskim Cyprze w XIV wieku. Protegowany kardynałów i brat arcybiskupa, pomimo pozornego braku wyższego wykształcenia, Périgordin Hélie otrzymał liczne beneficja i stanowiska, których kulminacją było ćwierć wieku jako w dużej mierze nieobecny biskup, najpierw Limassol, a (...) następnie Pafos. Istnieją jednak dowody na to, że miał duże doświadczenie w dyplomacji i administracji pod rządami swojego brata Filipa de Chambarlhac. W związku z tym dokładna analiza dokumentów papieskich ujawniła, że długa nieobecność Héliego na Cyprze wynikała z jego dwudziestoletniej służby jako stałego agenta królewskiego w kurii papieskiej, w czasie, gdy inne państwa również ustanawiały stałych ambasadorów w Awinionie. (shrink)

Since 1991 the Franciscan Francis of Marchia, master of theology at the University of Paris (fl. 1320), has begun receiving his due attention as an exciting and innovative thinker. This volume examines his doctrines in cosmology, physics, metaphysics, ethics, and politics.

While most researchers who use evolutionary theory to investigatehuman nature especially human sexuality describe themselves as ``interactionists'', there is no clear consensus on the meaning of thisterm in this context. By interactionism most people in the fieldmean something like, both nature and nurture ``count'' in thedevelopment of human psychology and behavior. Nevertheless, themultidisciplinary nature of evolutionary psychology results in a widevariety of interpretations of this general claim. Today, mostdebates within evolutionary psychology about the innateness of agiven behavioral characteristic or over (...) its development turn as muchon which conception of ``innateness'' and ``interactionism'' theresearcher holds as on any empirical data they might derive. (shrink)

Treating species as individuals and not classes has been crucial to the integration of evolutionary theory with modern systematics. Despite the theoretically important role the concept of individuality plays in modern phylogenetic systematics and in evolutionary theory more generally, many have been content to rely on common-sense intuitions about what counts as an individual. One of the most often cited intuitions is that individuals should be defined intrinsically. Unfortunately, common-sense intuitions like this one have proven to be inadequate for identifying (...) and characterizing historical individuals (like species). An examination of real-world biological examples shows that our common-sense intuitions are equally inadequate when applied to at least some biological organisms--the paradigm individuals. (shrink)

Philosophers and historians of science have tended to denigrate the status and usefulness of the practice of natural history. The development of biology in this century is seen as the replacement of an older, descriptive and speculative method with a quantitative, experimental and well-founded science. This account embodies a philosophical view about the nature of science, which deems certain kinds of evidence and certain ways of producing knowledge appropriate. Natural history is seen as inadequate, providing insufficient support for establishing theory. (...) ;I develop a case study which shows this account to be incorrect. The case study concerns the debate over the role of geographical isolation in speciation between 1905 and 1907. After some preliminary historical background to the debate, I present a detailed discussion of the arguments made by naturalist David Starr Jordan . The debate that ensued centered on the kinds of evidence one should use in doing science--fieldwork versus experiments. Thus, this case study offers excellent subject matter for understanding natural history. ;After examining the debate and its participants in some detail, we can see that at the heart of this debate is an epistemological issue over what virtues are central to science. In particular, while natural historians like Jordan were advocating an approach which emphasized the consilience of inductions--and hence a variety of kinds of evidence--a more experimentally oriented group of biologists were advocating the centrality of replication and hence argued that all non-experimental forms of evidence should be abandoned. Contrary to expectations, the naturalists had the better theory. (shrink)

Though only established as a discipline since the 1970s, philosophy of biology has already triggered investigations about its own history The Oxford handbook of philosophy of biology, Oxford University Press, New York, pp 11–33, 2008). When it comes to assessing the road since travelled—the research questions that have been pursued—manuals and ontologies also offer specific viewpoints, highlighting dedicated domains of inquiry and select work. In this article, we propose to approach the history of the philosophy of biology with a complementary (...) data-driven perspective that makes use of statistical algorithms applied to the complete full-text corpus of one major journal of the field—Biology and Philosophy—from its launch in 1986 up until 2017. By running text-mining and topic-modeling algorithms, we identified 67 key research topics that span across these 32 years. We also investigated the evolution of these topics over time and their fluctuating significance in the journal articles. Our results concur with known episodes or traits of the discipline—for instance, the significance of evolution-related topics or the decrease of articles with a marked historical dimension—but also highlight a diversity of topics that is much richer than what is usually acknowledged. (shrink)

Building on the recent scholarship of Bonnie Kent, Christian Trottmann, and especially L.M. de Rijk, this volume gathers together studies by other specialists on Odonis, covering his ideas in economics, logic, metaphysics, ethics, natural ...

As a discipline of its own, the philosophy of science can be traced back to the founding of its academic journals, some of which go back to the first half of the twentieth century. While the discipline has been the object of many historical studies, notably focusing on specific schools or major figures of the field, little work has focused on the journals themselves. Here, we investigate contemporary philosophy of science by means of computational text-mining approaches: we apply topic-modeling algorithms (...) to eight major philosophy of science journals, from the 1930s up until 2017. Based on the full-text content of some 15,897 articles, we identified 25 research themes and 8 thematic clusters that show how the research agenda of the philosophy of science has changed in its content over the course of the last eight decades, up to the philosophy of science we now know. We also show how each one of the journals contributed in its own way to this thematic evolution. (shrink)

Is behavioral integration a necessary feature of belief in folk psychology? Our data from over 5,000 people across 26 samples, spanning 22 countries suggests that it is not. Given the surprising cross-cultural robustness of our findings, we argue that the types of evidence for the ascription of a belief are, at least in some circumstances, lexicographically ordered: assertions are first taken into account, and when an agent sincerely asserts that p, nonlinguistic behavioral evidence is disregarded. In light of this, we (...) take ourselves to have discovered a universal principle governing the ascription of beliefs in folk psychology. (shrink)

Following the landmark corporate scandals of the early 21st century, there appeared to be a tremendous increase in the U.S. business media's emphasis on issues of ethics in corporate leadership. The purpose of this research was to examine whether that apparent increase was reflected in an actual change in that media's portrayals of successful leaders. We content analyzed the text of a total of 180 articles in Business Week, Fortune, and Forbes magazine, 90 from the five years preceding the landmark (...) scandals and 90 from the five years following the scandals. We found no evidence that the landmark scandals had any impact on the media's incorporation of ethics in their portrayals of leaders. We attribute this substantially to the persistence of a world-view in the U.S. business press that emphasizes leader traits and actions that have a direct impact on corporate profits. Additionally, we found some interesting consistencies and differences in media portrayals across the two time periods, likely related to the rise and fall of dot-com businesses. We discuss the implications of these findings for researchers and corporate leaders. (shrink)

Organisms and other biological entities are mistake-prone: they get things wrong. The entities of pure physics, such as atoms and inorganic molecules, do not make mistakes: they do what they do according to physical law, with no room for error except on the part of the physicist or their theory. We set out a novel framework for understanding biology and its demarcation from physics – that of mistake-making. We distinguish biological mistakes from mere failures. We then propose a rigorous definition (...) of mistakes that, although invoking the concept of function, is compatible with various views about what functions are. The definition of mistake-making is agential, since mistakes do not just happen ¬– at least in the sense analysed here – but are made. This requires, then, a notion of biological agency which we set out as a definition of the Minimal Biological Agent. The paper then considers a series of objections to the theory presented here, along with our replies. Two key features of our theory of mistakes are, first, that it is a supplement to, not a replacement for, existing general frameworks within which biology is understood and practised. Secondly, it is designed to be experimentally productive. Hence we end with a series of case studies where mistake theory can be shown to be useful in the potential generation of research questions and novel hypotheses of interest to the working biologist. (shrink)

A significant portion of the world’s text is tagged by readers on social bookmarking websites. Credit attribution is an inherent problem in these corpora because most pages have multiple tags, but the tags do not always apply with equal specificity across the whole document. Solving the credit attribution problem requires associating each word in a document with the most appropriate tags and vice versa. This paper introduces Labeled LDA, a topic model that constrains Latent Dirichlet Allocation by defining a one-to-one (...) correspondence between LDA’s latent topics and user tags. This allows Labeled LDA to directly learn word-tag correspondences. We demonstrate Labeled LDA’s improved expressiveness over traditional LDA with visualizations of a corpus of tagged web pages from del.icio.us. Labeled LDA outperforms SVMs by more than 3 to 1 when extracting tag-specific document snippets. As a multi-label text classifier, our model is competitive with a discriminative baseline on a variety of datasets. (shrink)

Illusionists and a posteriori physicalists agree entirely on the metaphysical nature of reality — that all concrete entities are composed of fundamental physical entities. Despite this basic agreement on metaphysics, illusionists hold that phenomenal consciousness does not exist, whereas a posteriori physicalists hold that it does. One explanation for this disagreement would be that either the illusionists have too demanding a view about what consciousness requires, or the a posteriori physicalists have too tolerant a view. However, we will argue that (...) this divergence of opinion is merely an upshot of the semantic indeterminacy of the term 'conscious' and its cognates. We shall back up this diagnosis by showing how semantic indeterminacy of the kind in question is a pervasive feature of language. By illustrating this pattern with a range of historical examples, we shall show how the dispute between the illusionists and a posteriori physicalists is one instance of a common kind of terminological imprecision. The disagreement between them is thus not substantial. In effect, the two sides differ only about how to make an indeterminate term precise. The moral is that they should stop looking for arguments designed to settle the dispute in their favour. (shrink)

This book collects essays from the 2006 and 2007 International Philosophy Colloquia Evian, centred around a central problem in the philosophy of mind: the relationship between the human faculty of sensory experience and the faculty of conceptual reflection, that is self-consciousness. Containing articles by philosophers of eight nationalities, in three languages (English, French, German), and of "analytical" as well as "continental" provenance, it beautifully represents the spirit of the colloquia. Authors include Joshua Andresen (AU Beirut), Valérie Aucouturier (Kent U / (...) U Paris I), Karin de Boer (KU Leuven), Santiago Echeverri (U Genève), Roberto Farneti (LU Bolzano), Tim Henning (JLU Giessen), Felix Koch (Columbia U), Christophe Laudou (Madrid), David Lauer (FU Berlin), Jason Leddington (Bucknell U), Nicolas Monseu (UC Louvain), Soraya Nour (HU Berlin), Hans Bernhard Schmid (U Wien), Henning Tegtmeyer (U Leipzig). (shrink)

We present a computer-supported approach for the logical analysis and conceptual explicitation of argumentative discourse. Computational hermeneutics harnesses recent progresses in automated reasoning for higher-order logics and aims at formalizing natural-language argumentative discourse using flexible combinations of expressive non-classical logics. In doing so, it allows us to render explicit the tacit conceptualizations implicit in argumentative discursive practices. Our approach operates on networks of structured arguments and is iterative and two-layered. At one layer we search for logically correct formalizations for each (...) of the individual arguments. At the next layer we select among those correct formalizations the ones which honor the argument’s dialectic role, i.e. attacking or supporting other arguments as intended. We operate at these two layers in parallel and continuously rate sentences’ formalizations by using, primarily, inferential adequacy criteria. An interpretive, logical theory will thus gradually evolve. This theory is composed of meaning postulates serving as explications for concepts playing a role in the analyzed arguments. Such a recursive, iterative approach to interpretation does justice to the inherent circularity of understanding: the whole is understood compositionally on the basis of its parts, while each part is understood only in the context of the whole. We summarily discuss previous work on exemplary applications of human-in-the-loop computational hermeneutics in metaphysical discourse. We also discuss some of the main challenges involved in fully-automating our approach. By sketching some design ideas and reviewing relevant technologies, we argue for the technological feasibility of a highly-automated computational hermeneutics. (shrink)

In the remainder of this article, we will disarm an important motivation for epistemic contextualism and interest-relative invariantism. We will accomplish this by presenting a stringent test of whether there is a stakes effect on ordinary knowledge ascription. Having shown that, even on a stringent way of testing, stakes fail to impact ordinary knowledge ascription, we will conclude that we should take another look at classical invariantism. Here is how we will proceed. Section 1 lays out some limitations of previous (...) research on stakes. Section 2 presents our study and concludes that there is little evidence for a substantial stakes effect. Section 3 responds to objections. The conclusion clears the way for classical invariantism. (shrink)

Do dissociations imply independent systems? In the memory field, the view that there are independent implicit and explicit memory systems has been predominantly supported by dissociation evidence. Here, we argue that many of these dissociations do not necessarily imply distinct memory systems. We review recent work with a single-system computational model that extends signal-detection theory (SDT) to implicit memory. SDT has had a major influence on research in a variety of domains. The current work shows that it can be broadened (...) even further in its range of application. Indeed, the single-system model that we present does surprisingly well in accounting for some key dissociations that have been taken as evidence for independent implicit and explicit memory systems. (shrink)

The prospect of extra‐terrestrial intelligence has become a central topic of scientific investigation and popular speculation. This has generated questions of ethical and theological significance that now receive growing coverage. Throughout his writings, Karl Rahner remained open to the prospect that the process of cosmic evolution had yielded sentient life form in other galaxies. He argued against any theological veto on this notion, while also distinguishing the existential significance of such life forms from that of angels. Furthermore, the possibility of (...) multiple incarnations is raised though not affirmed. With its christological intensity, his theology seems to militate against any repetition of the incarnation. This essay examines some of the arguments for and against the possibility of multiple incarnations, before assessing the current state of the extra‐terrestrial intelligence debate. In the light of inconclusive scientific findings, the cautionary position of Rahner is re‐affirmed. (shrink)

This article reviews recent work aimed at developing a new framework, based on signal detection theory, for understanding the relationship between explicit (e.g., recognition) and implicit (e.g., priming) memory. Within this framework, different assumptions about sources of memorial evidence can be framed. Application to experimental results provides robust evidence for a single-system model in preference to multiple-systems models. This evidence comes from several sources including studies of the effects of amnesia and ageing on explicit and implicit memory. The framework allows (...) a range of concepts in current memory research, such as familiarity, recollection, fluency, and source memory, to be linked to implicit memory. More generally, this work emphasizes the value of modern computational modelling techniques in the study of learning and memory. (shrink)

David Brown (b. 1948) is a Scottish Episcopal priest and theologian whose work covers a vast terrain spanning methodological divisions between philosophy, Christian theology, religious studies, the arts and culture. Early work on the Trinity and Incarnation led to a Newman-inspired articulation of Scripture as tradition, and, related to this, the exploration of tradition as revelation with reference to a wide range of human experience. Moving from materially-mediated divine presence to culturally-mediated revelation, Brown's phenomenology of religious experience amounts to (...) a transformed natural religion along sacramental lines. Essays in this volume consider Brown's wide ranging and generative contributions in three parts: 1) Butler & Newman, 2) Incarnation & Trinity, and 3) Sacramentality & the Arts, with a concluding response from Brown himself that addresses 'religious experience and revelation', as well as 'secular culture and religious distinctiveness'. (shrink)

Farm to School (FTS) programs are increasingly popular as methods to teach students about food, nutrition, and agriculture by connecting students with the sources of the food that they eat. They may also provide opportunity for farmers seeking to diversify market channels. Food service buyers in FTS programs often choose to procure food for school meals directly from farmers. The distribution practices required for such direct procurement often bring significant transaction costs for both school food service professionals and farmers. Analysis (...) of data from a survey of Vermont farmers who sell directly to school food services explores farmers’ motivations and distribution practices in these partnerships. A two-step cluster analysis procedure characterizes farmers’ motivations along a continuum between market-based and socially embedded values. Further bivariate analysis shows that farmers who are motivated most by market-based values are significantly associated with distribution practices that facilitate sales to school food services. Implications for technical assistance to facilitate these sales are discussed. (shrink)

Research on the implementation of corporate social responsibility (CSR) has revealed the critical role of CSR departments vis-à-vis functional departments. While both CSR and functional departments influence CSR implementation, the question of how they work together remains underexamined. We address this question by mobilizing and merging two complementary yet separate perspectives on CSR implementation: “coordination” and “enactment.” Building on a comparative case study involving seven large Swiss financial institutions that have established CSR departments and implemented CSR to varying extents, we (...) inductively derive six courses of actions conducing to CSR implementation, involving both coordination and enactment. We distinguish between four courses of actions in the CSR departments ( centralizing, coalescing, orchestrating, and consulting) and two courses of actions in the functional departments ( decentralizing and tailoring). As our data suggest that coordination and enactment work in tandem, we capture these insights in a model of CSR implementation as coordinated enactment. Our research contributes to the literature by explaining how CSR departments and functional departments enact and simultaneously coordinate CSR at a particular implementation stage, thus illuminating how and why the variance in CSR implementation occurs. (shrink)

It is the purpose of this special issue to acknowledge the shifting definitions and uses of the conceptual and empirical in the field of Science and Technology Studies, and to explore the constructive potential of this condition. In this introductory essay we point to four formulations in STS for the relation between the conceptual and the empirical which do not figure them as binaries or opposites: the empirical as a path to the conceptual, the conceptual as practical and empirical, the (...) empirical as an instantiation of the conceptual, and a conceptual minimalism. We then point to some inspirations in contemporary thought for engaging creatively with the conceptual and empirical, and conclude by summarizing the contributions to this issue. (shrink)

Species serve as both the basic units of macroevolutionary studies and as the basic units of taxonomic classification. In this paper I argue that the taxa identified as species by the Phylogenetic Species Concept (Mishler and Brandon 1987) are the units of biological organization most causally relevant to the evolutionary process but that such units exist at multiple levels within the hierarchy of any phylogenetic lineage. The PSC gives us no way of identifying one of these levels as the privileged (...) level on which taxonomic classifications can be based. (shrink)

We present a new modeling framework for recognition memory and repetition priming based on signal detection theory. We use this framework to specify and test the predictions of 4 models: (a) a single-system (SS) model, in which one continuous memory signal drives recognition and priming; (b) a multiple-systems-1 (MS1) model, in which completely independent memory signals (such as explicit and implicit memory) drive recognition and priming; (c) a multiple-systems-2 (MS2) model, in which there are also 2 memory signals, but some (...) degree of dependence is allowed between these 2 signals (and this model subsumes the SS and MS1 models as special cases); and (d) a dual-process signal detection (DPSD1) model, 1 possible extension of a dual-process theory of recognition (Yonelinas, 1994) to priming, in which a signal detection model is augmented by an independent recollection process. The predictions of the models are tested in a continuous-identification-with-recognition paradigm in both normal adults (Experiments 1–3) and amnesic individuals (using data from Conroy, Hopkins, & Squire,2005). The SS model predicted numerous results in advance. These were not predicted by the MS1 model, though could be accommodated by the more flexible MS2 model. Importantly, measures of overall model fit favored the SS model over the others. These results illustrate a new, formal approach to testing theories of explicit and implicit memory. (shrink)

An ambitious ethical theory ---Alan Gewirth's "Principle of Generic Consistency"--- is encoded and analysed in Isabelle/HOL. Gewirth's theory has stirred much attention in philosophy and ethics and has been proposed as a potential means to bound the impact of artificial general intelligence.

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

Over the past several years, various operational definitions of gender have been used in studies of gender conformity in homosexual males. The goal of these studies is to demonstrate that childhood gender nonconformity (CGN) is either the proximate cause of adult homosexuality or an intermediate step in a biologically mediated process. The hypothesis of a causal connection between the development of gender and sexual orientation is embedded within the context of a biological (evolutionary) understanding of human behavior. Thus, testing the (...) hypothesis of a causal connection between CGN and sexuality requires a concept of gender that is compatible with the basic principles of biological causation and our current understanding of evolutionary processes. I will argue that the concepts of gender used in the attempt to demonstrate a causal connection between CGN and sexual orientation are inappropriate because they provide no uniform, consistent method for identifying and measuring the biologically significant components of gender. I will also argue that the concept of gender that does emerge from these studies suggests an hypothesis about the connection between sexuality and gender that is not consistent with the cross-gendered theory of the etiology of homosexuality. (shrink)

Mistake-making is a common feature of life; it can be given a rigorous theoretical framework. The theory, though, faces a challenge from the ‘functions debate’. Perhaps mistakes are merely malfunctions, so a theory of mistakes requires a stance on functions. However, mistake theory views mistakes as distinct phenomena, not just malfunctions. The functions debate is largely separate from the concept of biological mistakes. While the selected effects theory, for instance, may retain its place within a pluralistic view of function, embracing (...) a robust concept of normativity that goes beyond a relatively narrow conception of function can drive future experimental research. (shrink)

Molecular tumour boards (MTBs) offer recommendations for potentially effective, but potentially burdensome, molecularly targeted treatments to a patient's treating physician. In this paper, we discuss the question of who is responsible for ensuring that there is an adequate evidence base for any treatments recommended to a patient. We argue that, given that treating oncologists cannot usually offer a robust evaluation of the evidence underlying an MTB's recommendation, members of the MTB are responsible for ensuring that the evidence level is adequate. (...) We explore two models for how to share responsibility between MTB members. According to the first model, each MTB member, as well as the treating physician, should be held maximally and equally responsible for the recommendations. We argue that this insufficiently accounts for differences in roles and expertise of MTB members. We propose instead that responsibility is delegated via relationships of trust. We argue if these relationships of trust are to be instances of reasonable trust, (a) MTBs should offer a clinical representative to whom a treating physician may delegate the responsibility of ensuring there is sufficient evidence for treatment recommendations, (b) the relationships of trust between the representative and the other MTB members should be clearly defined, and (c) MTB members should be carefully selected. Treating oncologists retain a responsibility to consider general limitations of the evidence for targeted treatments in assessing whether the treatment recommendation offered by an MTB's representative is adequate for a given clinical situation. (shrink)